Noncanonical Functions of Antibodies
Résumé
The canonical functions of antibodies are based on joining the process of antigen recognition with initiation of innate immune reactions. With the introduction of modern research approaches, and the use of sophisticated model systems, the recent years have witnessed the discovery of numbers of non-canonical functions of antibodies. These functions encompass either untypical strategies for neutralization of pathogens or exertion of activities by antibodies that are typically characteristic for other proteins (cytokines, chaperons or enzymes). Here we provide an overview of non-canonical functions of antibodies and discuss their mechanisms and implications for immune regulation and immune defence. A better comprehension of these functions will enrich our knowledge about the adaptive immune response and shall inspire the development of novel therapeutics.