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Welcome to the Sustainable Environment Group collection

The 'Sustainable Environment' research group focuses on the dissemination and impact of metals and emerging pollutants (nanomaterials, pharmaceutical compounds, etc.) on the chronic degradation of soil and water in relation to their use, as well as than on the valorization (agricultural recycling, critical metals, etc.) and the treatment of waste and wastewater. Whatever the system studied (soil, water, biota, materials), we share a common goal of a multi-scale systemic approach to understanding bio-physico-chemical processes and reaction mechanisms controlling the emission, transfer, accumulation, treatment and impact of contaminants and organic matter in our Environment.

Latest submissions in HAL !

[inserm-03109063] Pulmonary exposure to metallic nanomaterials during pregnancy irreversibly impairs lung development of the offspring

 (15/01/2021)  
Due to the growing commercial applications of manufactured nanoparticles (NPs), toxicological studies on NPs, especially during the critical window of development, are of major importance. The aim of the study was to assess the impact of respiratory exposure to metallic and metal oxide NPs during pregnancy on lung development of the offspring and to determine the key parameters involved in lung alterations. Pregnant mice were exposed to weekly doses of 100 μg (total dose 300 μg) of titanium dioxide (TiO2), cerium oxide (CeO2), silver (Ag) NPs or saline solution by nonsurgical intratracheal instillation. The offspring lungs were analyzed at different stages of lung development: fetal stage (gestational day 17.5), pulmonary alveolarization (post-delivery day 14.5) and lung maturity (post-delivery day 49.5). Regardless of the type of NP, maternal exposure during gestation induced long-lasting impairment of lung development of the offspring. This effect was accompanied by: i) decreased placental efficiency together with the presence of NPs in placenta, ii) no increase of inflammatory mediators present in amniotic fluid, placenta or offspring lungs and iii) decreased pulmonary expression of vascular endothelial growth factor-α (VEGF-α) and matrix metalloproteinase 9 (MMP-9) at the fetal stage, and fibroblast growth factor-18 (FGF-18) at the alveolarization stage. Respiratory exposure to metallic NPs during pregnancy induces stereotyped impairment of lung development with a lasting effect in adult mice, independently of the chemical nature of the NP.

[hal-03102046] The moon jellyfish as a new bioindicator: impact of silver nanoparticles on the morphogenesis

 (09/01/2021)  

[hal-01426264] An adaptable mesocosm platform for performing integrated assessments of nanomaterial risk in complex environmental systems

 (06/01/2021)  

 

 

Contact

Catherine Beaussier
Tél. (+33) 4 95 04 41 43
catherine.beaussier@osupytheas.fr

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