BIS2Analyzer: a server for co-evolution analysis of conserved protein families - Analytical Genomics Accéder directement au contenu
Article Dans Une Revue Nucleic Acids Research Année : 2017

BIS2Analyzer: a server for co-evolution analysis of conserved protein families

Résumé

Along protein sequences, co-evolution analysis identifies residue pairs demonstrating either a specific co-adaptation, where changes in one of the residues are compensated by changes in the other during evolution or a less specific external force that affects the evolutionary rates of both residues in a similar magnitude. In both cases, independently of the underlying cause, co-evolutionary signatures within or between proteins serve as markers of physical interactions and/or functional relationships. Depending on the type of protein under study, the set of available homologous sequences may greatly differ in size and amino acid variability. BIS2Analyzer, openly accessible at http://www.lcqb.upmc.fr/BIS2Analyzer/, is a web server providing the online analysis of co-evolving amino-acid pairs in protein alignments, especially designed for vertebrate and viral protein families, which typically display a small number of highly similar sequences. It is based on BIS2, a re-implemented fast version of the co-evolution analysis tool Blocks in Sequences (BIS). BIS2Analyzer provides a rich and interactive graphical interface to ease biological interpretation of the results.
Fichier principal
Vignette du fichier
gkx336.pdf (2.84 Mo) Télécharger le fichier
Origine : Publication financée par une institution
Loading...

Dates et versions

hal-01520493 , version 1 (10-05-2017)

Licence

Paternité

Identifiants

Citer

Francesco Oteri, Francesca Nadalin, Raphaël Champeimont, Alessandra Carbone. BIS2Analyzer: a server for co-evolution analysis of conserved protein families. Nucleic Acids Research, 2017, pp.W307-W314. ⟨10.1093/nar/gkx336⟩. ⟨hal-01520493⟩
422 Consultations
177 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More