Modeling NaV1.1/SCN1A sodium channel mutations in a microcircuit with realistic ion concentration dynamics suggests differential GABAergic mechanisms leading to hyperexcitability in epilepsy and migraine

Louisiane Lemaire (1, 2) , Mathieu Desroches (1, 2) , Martin Krupa (1, 3) , Lara Pizzamiglio (4) , Paolo Scalmani (5) , Massimo Mantegazza (4, 6)

1 MATHNEURO - Mathématiques pour les Neurosciences
2 UniCA - Université Côte d'Azur
3 LJAD - Laboratoire Jean Alexandre Dieudonné
4 IPMC - Institut de pharmacologie moléculaire et cellulaire
5 Fondazione IRCCS Istituto Neurologico "Carlo Besta"
6 INSERM - Institut National de la Santé et de la Recherche Médicale

Domaines: Modélisation et simulation; Neurosciences

Louisiane Lemaire, Mathieu Desroches, Martin Krupa, Lara Pizzamiglio, Paolo Scalmani, et al.. Modeling NaV1.1/SCN1A sodium channel mutations in a microcircuit with realistic ion concentration dynamics suggests differential GABAergic mechanisms leading to hyperexcitability in epilepsy and migraine. 2021. ⟨hal-03191275v1⟩